From 2015 to 2016, she starred as the titular character in the historical drama series Muhteşem Yüzyıl: Kösem – for which she was said to be receiving 90,000 per episode.

She has participated in several movies as a voice actor.

Hamdi Alkan, a member of Türkiye'nin Yıldızları jury was interviewed and detailed information about Beren Saat.

For her role in the series, she won two Golden Butterfly Awards, and was the first nominee to win the award for two consecutive years.

She was then prepared by Tomris Giritlioğlu for her first major role in Aşka Sürgün (2005–2006).

She starred as a feisty tomboy named Yasemin Ünsal in the ATV's political series Hatırla Sevgili (2006–2008) and came to international attention for her role as Bihter Yöreoğlu Ziyagil, an unfaithful wife, in the Kanal D's romantic series Aşk-ı Memnu (2008–2010), for which she received critical acclaim and won numerous accolades, including two Golden Butterfly Awards.

During her studies in Başkent University, she participated in the acting competition Türkiye'nin Yıldızları and was discovered by Turkish director Tomris Giritlioğlu, upon which she started her professional acting career.

Saat made her acting debut with a minor part in the television series Aşkımızda Ölüm Var (2004).

She shared the leading role with Cansel Elçin and Okan Yalabık.

The series focused on the political events occurred during 1950–70 and Saat achieved great success and nationwide fame during the period of its broadcast.

a screenplay adaptation of the movie written by Vedat Türkali in 1986.